- Bajoran Republic
- Breen Confederacy
- Cardassian Union
- Ferengi Alliance
- Orion Syndicate
- Klingon Empire
- Kzinti Government
- Romulan Star Empire
- Talarian Republic
- Tholian Assembly
- United Federation of Planets
- Aaamazzara
- Alshain IV
- Andoria
- Bajor
- Ba'ku
- Barzan II
- Benzar
- Betazed
- Bolarus IX
- Breen
- Cardassia Prime
- Ceti Alpha V
- Delta IV
- Deneb IV
- Earth
- Ferenginar
- Illyria
- Minos
- Mizar II
- Ni'Var
- Orion
- Risa
- Talos IV
- Tellar Prime
- Trill
- Vagra II
- Arachnid Nebula
- Badlands
- Bajoran Wormhole (One End)
- Barzan Wormhole
- Briar Patch
- 4.5 million years ago: Progenitors seed the galaxy with genetically compatible life
- 4th Century: Ancient Vulcan–Romulan Split
- 2063: Zefram Cochrane invents warp drive, makes first Contact with Vulcans
- 2161: United Federation of Planets was founded
- 2250s–2260s: Federation vs Klingon Empire
- 2293: Khitomer Accords signed
- 2344: Battle of Narendra III
- 2366: Borg invasion, Battle of Wolf 359
- 2369: Cardassians withdraw from Bajor, Bajoran Wormhole discovered
- 2373–2375: Dominion War
- 2387: Romulus destroyed by supernova
- 2399–2401: Rogue Changelings & Borg attack the Federation
- 3069: The Burn
- 3089: Federation collapsed
- 3189–3190: Rebirth of the Federation
- Adjacent to the Beta & Gamma Quadrants
