The auto-destruct system (also known as self-destruct or destruct sequence) was a starship system that allowed the total destruction of the vessel. This was typically activated as a last resort, usually to prevent a ship from falling into enemy hands.

On Starfleet vessels, the activation sequence varied from class to class but usually required authorization with the use of command authorization codes. Once the countdown was activated, the ship's computer could give audio warnings and/or displayed countdown warning graphics on viewscreens and terminals, though this featured could be disabled when initiating the sequence. It could also be aborted by voice command.