Darla

Worked as a prostitute, contracted a fatal case of syphilis
1609: Sired by the Master, he gave her the name "Darla"
1753: Visited a village in Galway, Ireland, Sired Liam & named him Angelus
1898: Gifted Angelus with the daughter of the Kalderash tribe, he was cured with a soul
1900: Traveled to China during the Boxer Rebellion, developed a taste for religious wars
1997: Staked by Angel during a fight with the Slayer & "Scooby Gang"
200: Resurrected as a human by Wolfram & Hart in an attempt to weaken Angel
2001: Embraced her humanity & soul, turned back into a vampire by Drusilla;
Fought with Angel, became pregnant, sacrificed herself to allow her son to be born