Blue Kryptonite is a mineral from the planet Krypton that can strips super-powered Kryptonians of all their abilities.

It renders mortal and, thus, susceptible to damage and pain as with any human. It is possible that the substance does this by turning off the manifestation of genes that allow Kryptonians to process sunlight while in contact with it. Blue kryptonite can also render a Kryptonian immune to the effects of green kryptonite.

This form of kryptonite can drastically improve the health of any non-Kryptonian organism, such as livestock, crops, and humans. Continual consumption of blue kryptonite-irradiated water puts humans in a perfect state of health.

If used on Bizarro, it would magnify his powers and could cause him to explode.