Lana Lang

Adopted & raised by her aunt following the deaths of her parents in the meteor shower
Tried to have a relationship with Clark several times, never worked due to his secret
Established & managed the Talon, a local coffee shop, Coo-owned it with Lex Luthor
Possessed by Isobel, who used her to continue her search for the Stones of Knowledge
Witnessed two aliens come out of the Black Ship, worked with Lex to discover the truth
Manipulated by Lex, he set up a fake pregnancy in order to get her to marry him;
Discovered the truth, divorced him & faked her death, framing Lex for her murder
Founded the Isis Foundation to provide help for meteor-infected individuals
Learnt about Clark’s powers, forced to leave Smallville by Tess Mercer
Fused with a Power suit, which gave her powers, including Kryptonite radiation absorption
Resumed her relationship with Clark, forced to defuse a Kryptonite bomb, planted by Lex;
Absorbed so much Kryptonite radiation that Clark could never get close to her again
Moved to Africa, operated as a vigilante, protected local villages from African warlords
Lost her powers after fighting Metallo, continues doing philanthropic work in Africa