The USS Reliant (NCC-1864) was a 23rd century Federation Miranda-class starship operated by Starfleet. In 2285, the Reliant was commanded by Captain Clark Terrell.

In 2285, the Reliant was assigned to assist Carol Marcus and Project Genesis. Reliant searched for a lifeless planet to satisfy the stringent requirements necessary for stage three of the experiment. While searching for that planet, they went to Ceti Alpha VI.

The landing party, however, instead discovered a group of exiles, led by Khan Noonien Singh. Khan and his followers quickly captured the two Starfleet officers and informed them that the planet Reliant was orbiting was not Ceti Alpha VI but actually Ceti Alpha V. The Reliant was ultimately destroyed inside the nebula by Khan's detonation of the Genesis Device.