Adjacent to the Beta & the Gamma Quadrants
- Kazon
- Talaxians
- Ocampans
- Borg
- Vidiians
- Hirogen
- Krenim
- Vau N'Akat
- Akritiri
- Banea
- Brunali homeworld
- Devore Prime
- Drayan II
- Enara Prime
- Kraylor Prime
- Kyrian & Vaskan homeworld
- Krenna
- Ocampa
- Quarra
- Qomar
- Sikaris
- Silver Blood homeworld
- Tahal-Meeroj
- Talax
- Vidiian homeworld
- The Waters
- Harry Kim Wormhole
- Nekrit Expanse
- The Void (Encased in an inert layer of subspace)
- The Void (Vast region with no star systems)
- Toxic Nebula
- Millions of years ago: Voth left Earth, established a civilization
- 3rd Century: The Phage spread throughout the Vidiian Sodality
- 15th Century: Vaadwaur controlled many colonies, defeated by the Turei
- 1937: Humans were planted in the Quadrant by the Briori
- 2346: Jal Sankur united the Kazon sects to overthrow the Trabe
- 2371: Voyager was sent to this Quadrant by the Caretaker
- 2378: Voyager returned to the Alpha Quadrant